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This figure is a 3D computer reconstruction of 3 excitatory neurons (blue neurons), called pyramidal neurons in the Neocortex together with a single inhibitory neurons (white) called a small basket cell. The neurons were captured in an experiment that revealed how the small inhibitory neuron sends information to the 3 excitatory neurons in order to control their activity. The control of excitability in the brain is important for normal information processing and also to prevent hyperexcitable states such as epilepsy.

Bibliography

DeFelipe J (2002) Cortical interneurons: From Cajal to 2001. Prog Brain Res 136:215-238.

Peters A, Jones EG (eds) (1984) Cerebral Cortex. Cellular Components of the Cerebral Cortex. Vol. 1. New York: Plenum Press.

Markram H, Toledo-Rodriguez M, Wang Y, Gupta A, Silberberg G, Wu C (2004)

Interneurons of the neocortical inhibitory system. Nat Rev Neurosci 5:793-807.

Somogyi P, Tamás G, Lujan R, Buhl EH (1998) Salient features of synaptic organisation in the cerebral cortex. Brain Res Rev 26:113-135.

Valverde F (1985) The organizing principles of the primary visual cortex in the monkey. In Peters A, Jones EG eds. Cerebral Cortex. Visual Cortex Vol 3 New York: Plenum Press, 207-257.

 

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